Invention Grant
- Patent Title: Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors
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Application No.: US14647940Application Date: 2013-10-31
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Publication No.: US09604980B2Publication Date: 2017-03-28
- Inventor: Maria Menichincheri , Mauro Angiolini , Jay Aaron Bertrand , Michele Caruso , Paolo Polucci , Francesca Quartieri , Barbara Salom , Matteo Salsa , Fabio Zuccotto
- Applicant: NERVIANO MEDICAL SCIENCES S.r.l
- Applicant Address: IT Nerviano (MI)
- Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
- Current Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
- Current Assignee Address: IT Nerviano (MI)
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP12191679 20121107
- International Application: PCT/EP2013/072793 WO 20131031
- International Announcement: WO2014/072220 WO 20140515
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/506 ; A61K45/06 ; A61K31/496 ; A61N5/10
Abstract:
The present invention relates to substituted pyrimidinyl- and pyridinylpyrrolopyridinone compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
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