Invention Grant
- Patent Title: Agent for treating or inhibiting recurrence of acute myeloid leukemia
-
Application No.: US14417250Application Date: 2013-07-29
-
Publication No.: US09604988B2Publication Date: 2017-03-28
- Inventor: Fumihiko Ishikawa , Yoriko Saito , Yoshinobu Hashizume , Yasuko Koda , Hitomi Yuki
- Applicant: RIKEN
- Applicant Address: JP Saitama
- Assignee: RIKEN
- Current Assignee: RIKEN
- Current Assignee Address: JP Saitama
- Agency: Foley & Lardner LLP
- Priority: JP2012-167553 20120727
- International Application: PCT/JP2013/070436 WO 20130729
- International Announcement: WO2014/017659 WO 20140130
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61K31/4985 ; A61P35/02 ; A61K45/06 ; A61K31/4709 ; A61K31/7105 ; A61K31/713 ; C07D519/00 ; C12Q1/68

Abstract:
This invention relates to an agent for treating or inhibiting recurrence of acute myeloid leukemia and an agent for inhibiting growth of leukemia stem cells comprising a compound represented by formula (I) or a salt thereof: wherein Ar1 and Ar2 each represent aryl or heteroaryl; L represents O, S, NH, NHCO, or CONH; X represents CH or N; Y represents C1-3-alkylene; Z1 represents hydrogen, C1-6-alkyl, amino-C1-6-alkyl, C1-6-alkylamino-C1-6-alkyl, di(C1-6-alkyl)amino-C1-6-alkyl, hydroxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl, or carboxy-C1-6-alkyl; and Z2 represents C1-6-alkyl, amino-C1-6-alkyl, C1-6-alkylamino-C1-6-alkyl, di(C1-6-alkyl)amino-C1-6-alkyl, hydroxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl, or carboxy-C1-6-alkyl, Z1 and Z2 may, together with adjacent nitrogen, form a heterocyclic group containing as a ring member one or more hetero atoms, in addition to the nitrogen adjacent to Z1 and Z2.
Public/Granted literature
- US20150210698A1 AGENT FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA Public/Granted day:2015-07-30
Information query