Invention Grant
- Patent Title: Polyene compound, method for preparing the same, and antifungal drug comprising novel polyene compound as active ingredient
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Application No.: US14369869Application Date: 2012-08-31
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Publication No.: US09605015B2Publication Date: 2017-03-28
- Inventor: Eung-Soo Kim , Kyu Boem Han , Shuangjun Lin , Dekun Kong , Linquan Bai , Zixin Deng , David H. Sherman , Mi-Jin Lee
- Applicant: Eung-Soo Kim , Kyu Boem Han , Shuangjun Lin , Dekun Kong , Linquan Bai , Zixin Deng , David H. Sherman , Mi-Jin Lee
- Applicant Address: KR Incheon
- Assignee: INHA-INDUSTRY PARTNERSHIP INSTITUTE
- Current Assignee: INHA-INDUSTRY PARTNERSHIP INSTITUTE
- Current Assignee Address: KR Incheon
- Agency: Schwegman Lundberg & Woessner, P.A.
- Priority: KR10-2011-0147050 20111230
- International Application: PCT/KR2012/007000 WO 20120831
- International Announcement: WO2013/100315 WO 20130704
- Main IPC: C07H15/26
- IPC: C07H15/26 ; C12P19/62 ; C07H17/08 ; C07D493/08
Abstract:
The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.
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