• Patent Title: Method of esterification of carboxyl groups present on multihydroxyl cyclic polyene molecular structures carrying basic nitrogen groups
  • Application No.: US14816114
    Application Date: 2015-08-03
  • Publication No.: US09605016B2
    Publication Date: 2017-03-28
  • Inventor: Alberto Milanese
  • Applicant: Alberto Milanese
  • Agency: Silvia Salvadori, P.C.
  • Agent Silvia Salvadori
  • Main IPC: C07H17/08
  • IPC: C07H17/08
Method of esterification of carboxyl groups present on multihydroxyl cyclic polyene molecular structures carrying basic nitrogen groups
Abstract:
Disclosed is a process for the preparation of partricin alkyl esters which involves reacting partricin in a solvent with primary alkyl alcohols in the quantity of 5 to 1000 moles per mole of partricin in the presence of carbodiimides, and optionally in the presence of acylation catalysts and/or nitrogen bases or anhydrous acids.
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