According to some embodiments of the invention, an endoscope sleeve comprises a sleeve defining a lumen for accepting an endoscope in a slidable manner, the sleeve having a proximal end configured to accept the endoscope and a distal end configured to be slidably disposed over the endoscope, wherein the sleeve comprises a compact configuration and an extended configuration. The endoscope sleeve further comprises a retainer configured to be detachably attached to the sleeve, wherein in the compact configuration the retainer is attached to the sleeve and in the extended configuration the retainer is detached from the sleeve allowing the sleeve to be extendable over the endoscope.