Invention Grant
- Patent Title: Small molecule inhibitors of RNA binding motif (RBM) proteins for the treatment of acute cellular injury
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Application No.: US14401088Application Date: 2013-05-14
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Publication No.: US09610266B2Publication Date: 2017-04-04
- Inventor: Travis Corey Jackson , Jonathan D. Verrier , Patrick Kochanek
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2013/040995 WO 20130514
- International Announcement: WO2013/173370 WO 20131121
- Main IPC: A61K31/185
- IPC: A61K31/185 ; C12N15/113 ; A61K31/167 ; A61K31/192 ; A61K31/44 ; A61K31/4418 ; A61K31/52 ; A61K31/551 ; A61K31/713

Abstract:
A method of treating a cellular injury in a subject comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of formula I: wherein at least one of R1-R8 is a sulfonic acid, a carboxylic acid, a phosphonic acid, a pharmaceutically acceptable salt of a sulfonic acid, a pharmaceutically acceptable salt of a carboxylic acid, a pharmaceutically acceptable salt of a phosphonic acid, a sulfonate ester, a carboxylate acid ester, or a phosphonate ester; and the remaining R1-R8 are each independently selected from hydrogen, halo, hydroxyl, nitro, nitroso, amino, substituted amino, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoy, alkenyloxy, substituted alkenyloxy, alkynyloxy, substituted alkynyloxy, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkynyl, substituted cycloalkynyl, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyl, substituted heterocyclyl, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylthio, substituted heterocyclylthio, cyano, acyl, acylamino, acyloxy, aminocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, arylthio, substituted arylthio, alkylthio, substituted alkylthio, cycloalkylthio, substituted cycloalkylthio, cycloalkenylthio, substituted cycloalkenylthio, thiol, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heteroarylthio, substituted heteroarylthio, sulfonyl, or sulfonyloxy.
Public/Granted literature
- US20150141488A1 SMALL MOLECULE INHIBITORS OF RNA BINDING MOTIF (RBM) PROTEINS FOR THE TREATMENT OF ACUTE CELLULAR INJURY Public/Granted day:2015-05-21
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