Invention Grant
- Patent Title: Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1
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Application No.: US13582900Application Date: 2011-03-07
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Publication No.: US09610328B2Publication Date: 2017-04-04
- Inventor: David J. Mooney , Cristina Borselli , Herman Vandenburgh , Dimitry Shvartsman , Hannah Storrie , Jeff Lichtman
- Applicant: David J. Mooney , Cristina Borselli , Herman Vandenburgh , Dimitry Shvartsman , Hannah Storrie , Jeff Lichtman
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Maria Lacocotripe Zacharakis
- International Application: PCT/US2011/027446 WO 20110307
- International Announcement: WO2011/109834 WO 20110909
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C12N5/00 ; A61K38/18 ; A61K38/30 ; A61L27/36 ; A61L27/38 ; A61L27/52 ; A61L27/54 ; A61L27/56 ; A61K35/34 ; A61K35/12
Abstract:
An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.
Public/Granted literature
- US20130177536A1 Enhancement Of Skeletal Muscle Stem Cell Engraftment By Dual Delivery Of VEGF And IGF-1 Public/Granted day:2013-07-11
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