Invention Grant
![Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone](/docs/US/2017-04-04/US09611201B2/abs.jpg.600x600.jpg)
- Patent Title: Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
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Application No.: US15059627Application Date: 2016-03-03
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Publication No.: US09611201B2Publication Date: 2017-04-04
- Inventor: Stéphane De Lombaert , Daniel R. Goldberg
- Applicant: Karos Pharmaceuticals, Inc.
- Applicant Address: US CT New Haven
- Assignee: Karos Pharmaceuticals, Inc.
- Current Assignee: Karos Pharmaceuticals, Inc.
- Current Assignee Address: US CT New Haven
- Agency: Fish & Richardson P.C.
- Main IPC: C07C29/32
- IPC: C07C29/32 ; C07C29/143 ; C07C259/10 ; C07C45/45 ; C07C49/80
![Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone](/abs-image/US/2017/04/04/US09611201B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.
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