Invention Grant
- Patent Title: Substituted piperidine compounds and their use as orexin receptor modulators
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Application No.: US14774529Application Date: 2014-03-12
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Publication No.: US09611251B2Publication Date: 2017-04-04
- Inventor: Heather R. Coate , Curt A. Dvorak , Cathy Preville , Brock T. Shireman
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agency: Baker & Hostetler LLP
- International Application: PCT/US2014/024284 WO 20140312
- International Announcement: WO2014/165065 WO 20141009
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A01N43/60 ; A61K31/50 ; A61K31/495 ; A01N43/54 ; C07D239/42 ; C07D401/04 ; A61K31/505 ; A01N43/40 ; A61K31/445 ; C07D401/00 ; C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D401/12 ; C07D401/14 ; C07D413/14 ; C07D413/12 ; C07D417/14

Abstract:
The present invention is directed to compounds of Formula I: wherein X is CR1 or N; Y is CR2 or N; Z is NH or O; R1 is alkoxy, triazolyl, oxazolyl, isoxazolyl, oxadiazolyl, or pyrimidinyl; R2 is H, alkyl, or halo; R3 is H, alkyl, alkoxy, halo, triazolyl, oxazolyl, or pyrimidinyl; R4 is alkyl; R5 is pyridyl; benzoxazolyl; pyrimidinyl; pyridazinyl; quinoxalinyl; pyrazinyl; or quinazolinyl; wherein the pyridyl; benzoxazolyl; pyrimidinyl; pyridazinyl; quinoxalinyl; pyrazinyl; or quinazolinyl is optionally substituted with one or two substituents independently selected from the group consisting of alkyl, halo, or phenyl; and R6 is H or alkyl. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods using the compounds of the invention are also within the scope of the invention.
Public/Granted literature
- US20160046599A1 SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS Public/Granted day:2016-02-18
Information query
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