Invention Grant
- Patent Title: Macrocycles as factor XIa inhibitors
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Application No.: US14942013Application Date: 2015-11-16
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Publication No.: US09611274B2Publication Date: 2017-04-04
- Inventor: Donald J. P. Pinto , James R. Corte , Paul J. Gilligan , Tianan Fang , Leon M. Smith, II , Yufeng Wang , Wu Yang , William R. Ewing
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- Main IPC: C07D487/08
- IPC: C07D487/08 ; C07D498/06 ; C07D471/06 ; C07D487/06

Abstract:
The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20160068544A1 NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS Public/Granted day:2016-03-10
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