Invention Grant
- Patent Title: Substituted 2-azabicycles and their use as orexin receptor modulators
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Application No.: US14774555Application Date: 2014-03-12
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Publication No.: US09611277B2Publication Date: 2017-04-04
- Inventor: Christine F. Gelin , Terry P. Lebold , Brock T. Shireman , Jeannie M. Ziff
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agency: Baker & Hostetler LLP
- International Application: PCT/US2014/024293 WO 20140312
- International Announcement: WO2014/165070 WO 20141009
- Main IPC: C07D401/00
- IPC: C07D401/00 ; C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D411/00 ; C07D413/00 ; C07D417/00 ; C07D419/00 ; C07D421/00 ; C07D513/04 ; C07D413/14 ; C07D401/12 ; C07D401/14 ; C07D403/14 ; C07D471/08 ; C07D487/08 ; C07D519/00 ; A61K31/4439 ; A61K31/444 ; A61K31/4709 ; A61K31/4725 ; A61K31/497 ; A61K31/506 ; C07D405/14 ; C07D417/14

Abstract:
The present invention is directed to compounds of Formula I: wherein X is N or CR1; Y is N or CR2; R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl; R2 is H, alkyl, alkoxy, or halo; Z is NH or O; R3 is H, alkyl, alkoxy, halo, or triazolyl; R4 is H or alkyl; or R3 and R4, together with the atoms to which they are attached, form a 6-membered aryl ring or a 5- or 6-membered heteroaryl ring; R5 is pyridyl, pyrazinyl, or pyrimidinyl, wherein the pyridyl, pyrazinyl, or pyrimidinyl is optionally substituted with halo or alkyl; and n is 1 or 2. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
Public/Granted literature
- US20160052939A1 SUBSTITUTED 2-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS Public/Granted day:2016-02-25
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