Invention Grant
- Patent Title: High-transduction-efficiency RAAV vectors, compositions, and methods of use
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Application No.: US14401442Application Date: 2013-05-15
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Publication No.: US09611302B2Publication Date: 2017-04-04
- Inventor: Arun Srivastava , George Vladimirovich Aslanidi , Kim M. Van Vliet , Mavis Agbandje-Mckenna
- Applicant: University of Florida Research Foundation, Inc.
- Applicant Address: US FL Gainesville
- Assignee: University of Florida Research Foundation, Inc.
- Current Assignee: University of Florida Research Foundation, Inc.
- Current Assignee Address: US FL Gainesville
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2013/041234 WO 20130515
- International Announcement: WO2013/173512 WO 20131121
- Main IPC: C12N15/86
- IPC: C12N15/86 ; C07K14/005
Abstract:
The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions.
Public/Granted literature
- US20150133530A1 HIGH-TRANSDUCTION-EFFICIENCY RAAV VECTORS, COMPOSITIONS, AND METHODS OF USE Public/Granted day:2015-05-14
Information query
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