Invention Grant
- Patent Title: Active protease-resistant antibody FC mutants
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Application No.: US14492250Application Date: 2014-09-22
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Publication No.: US09611328B2Publication Date: 2017-04-04
- Inventor: Randall Brezski , Robert Jordan , William Strohl
- Applicant: JANSSEN BIOTECH, INC.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agent Kenneth J. Dow
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K16/00 ; C07K16/30 ; C07K16/22 ; C07K16/28 ; C07K16/40
Abstract:
The present invention relates to modified Fc-containing molecules including modified antibodies characterized by increased resistance to host and pathogen-derived proteases, ability to interact with FcγR receptors except with FcγRI, and lack of induction of IL-10 secretion by macrophages, and methods of using and making them.
Public/Granted literature
- US20150139984A1 ACTIVE PROTEASE-RESISTANT ANTIBODY FC MUTANTS Public/Granted day:2015-05-21
Information query
IPC分类:
