Invention Grant
- Patent Title: Triazine derivatives as differentiation catalysts
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Application No.: US14346328Application Date: 2012-09-21
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Publication No.: US09611457B2Publication Date: 2017-04-04
- Inventor: Marko Mihovilovic , Michael Schnuerch , Karlheinz Hilber , Xaver Koenig , Thomas Linder , Agnes Mike
- Applicant: Marko Mihovilovic , Michael Schnuerch , Karlheinz Hilber , Xaver Koenig , Thomas Linder , Agnes Mike
- Applicant Address: AT Vienna
- Assignee: TECHNISCHE UNIVERSITAET WIEN
- Current Assignee: TECHNISCHE UNIVERSITAET WIEN
- Current Assignee Address: AT Vienna
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: ATA1364/2011 20110921
- International Application: PCT/AT2012/050140 WO 20120921
- International Announcement: WO2013/040622 WO 20130328
- Main IPC: C12N5/071
- IPC: C12N5/071 ; C12N5/077 ; C07D251/44 ; C07D251/46 ; C07D251/48 ; C07D251/50

Abstract:
A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently —NR4—or —O—, R4 is hydrogen or C1-6-alkyl; R1 is hydroxy, C1-6-alkyl, C1-6-alkoxy, carboxy, C1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C1-6-alkylamino, or di-C1-6-alkylamino, the C1-6-alkyl or -alkoxy residue being optionally substituted with one or more R5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; R2 is hydrogen, aryl, heteroaryl, or C1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more R1 substituents, and where the C1-6-alkyl is optionally further substituted with one or more R5 substituents; and R3 is selected from hydrogen, halo, NR4R7, OR7, SR7, and R7, where the same options apply for R7 as for R2; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.
Public/Granted literature
- US20140234965A1 TRIAZINE DERIVATIVES AS DIFFERENTIATION CATALYSTS Public/Granted day:2014-08-21
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