Invention Grant
- Patent Title: REF nuclease for site-specific REF-mediated DNA cleavage
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Application No.: US14336828Application Date: 2014-07-21
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Publication No.: US09611470B2Publication Date: 2017-04-04
- Inventor: Michael Matthew Cox , Angela Jo Gruber , Tayla Maria Olsen
- Applicant: Wisconsin Alumni Research Foundation
- Agency: Quarles & Brady, LLP
- Main IPC: C12N15/01
- IPC: C12N15/01 ; C12N9/22 ; C07K14/005
Abstract:
Purified Ref polypeptides with increased nuclease site-specific targeting activity, recombinant nucleic acids and cells for expression of such Ref polypeptides, and methods for using the Ref polypeptides in combination with RecA protein and variants thereof to effect targeted nuclease cleavage of a DNA duplex are disclosed.
Public/Granted literature
- US20150023943A1 REF Nuclease for Site-Specific REF-Mediated DNA Cleavage Public/Granted day:2015-01-22
Information query
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