Invention Grant
- Patent Title: Antisense oligonucleotide directed removal of proteolytic cleavage sites from proteins
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Application No.: US13814203Application Date: 2011-08-04
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Publication No.: US09611471B2Publication Date: 2017-04-04
- Inventor: Wilhelmina M. C. van Roon-Mom , Melvin Maurice Evers , Barry Antonius Pepers , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
- Applicant: Wilhelmina M. C. van Roon-Mom , Melvin Maurice Evers , Barry Antonius Pepers , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
- Applicant Address: NL Leiden
- Assignee: Academisch Ziekenhuis Leiden
- Current Assignee: Academisch Ziekenhuis Leiden
- Current Assignee Address: NL Leiden
- Agency: TraskBritt P.C.
- Priority: EP10172076 20100805
- International Application: PCT/NL2011/050549 WO 20110804
- International Announcement: WO2012/018257 WO 20120209
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/11
Abstract:
Described are means and methods for removing a proteolytic cleavage site from a protein, the method comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, and allowing translation of mRNA produced from the pre-mRNA.
Public/Granted literature
- US20130198877A1 ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES FROM PROTEINS Public/Granted day:2013-08-01
Information query
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