Invention Grant
- Patent Title: Crosslinked nucleoside and nucleotide
-
Application No.: US15118546Application Date: 2015-02-17
-
Publication No.: US09611479B2Publication Date: 2017-04-04
- Inventor: Satoshi Obika , Takao Yamaguchi , Masahiko Horiba , Reiko Waki
- Applicant: OSAKA UNIVERSITY
- Applicant Address: JP Osaka
- Assignee: Osaka University
- Current Assignee: Osaka University
- Current Assignee Address: JP Osaka
- Agency: Renner, Otto, Boisselle & Sklar, LLP
- Priority: JP2014-028210 20140218
- International Application: PCT/JP2015/054308 WO 20150217
- International Announcement: WO2015/125783 WO 20150827
- Main IPC: C07H19/06
- IPC: C07H19/06 ; C07H19/16 ; C12N15/113

Abstract:
Disclosed are bridged nucleosides and nucleotides. The nucleosides of the present invention have a 2′,4′-bridged structure and are represented by formula I below: An oligonucleotide containing a 2′,4′-bridged artificial nucleotide of the present invention has a binding affinity for single-stranded RNA comparable to that of known 2′,4′-BNA/LNA and higher nuclease resistance than LNA. In particular, since the oligonucleotide has a much higher binding affinity for single-stranded RNA than S-oligo, it is expected that the oligonucleotide is applicable to nucleic acid drugs.
Public/Granted literature
- US20170044528A1 CROSSLINKED NUCLEOSIDE AND NUCLEOTIDE Public/Granted day:2017-02-16
Information query
IPC分类: