Invention Grant
- Patent Title: Method for selection of hDIS3 PIN domain inhibitors and use of hDIS3 PIN domain inhibitors for cancer treatment
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Application No.: US14892000Application Date: 2014-05-20
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Publication No.: US09611514B2Publication Date: 2017-04-04
- Inventor: Andrzej Dziembowski , Rafal Tomecki , Karolina Drazkowska , Roman Szczesny , Krystian Stodus , Weronika Jonko , Marcin Nowotny , Adam Golebiowski , Jacek Olczak
- Applicant: INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK , ONCOARENDI THERAPEUTICS SP ZOO , MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE
- Applicant Address: PL Warsaw PL Warsaw PL Warsaw
- Assignee: INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK,ONCOARENDI THERAPEUTICS SP ZOO,MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE
- Current Assignee: INSTYTUT BIOCHEMII I BIOFIZYKI POLSKIEJ AKADEMII NAUK,ONCOARENDI THERAPEUTICS SP ZOO,MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE
- Current Assignee Address: PL Warsaw PL Warsaw PL Warsaw
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Deborah L. Lu
- Priority: PLP.403980 20130521
- International Application: PCT/IB2014/061558 WO 20140520
- International Announcement: WO2014/188337 WO 20141127
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/18 ; G01N33/573 ; G01N33/50 ; A61K31/472 ; C12N15/81
Abstract:
The present invention relates to a method for selection or screening of hDIS3 PIN domain inhibitors, yeast strain and cell line used in such methods It also relates to new therapeutic agents selected hDIS3 PIN domain inhibitors and uses thereof in the treatment of cancers having mutations inhDIS3 RNB domain, especially multiple myeloma. The invention also relates to composition comprising new therapeutic agent hDIS3 PIN domain inhibitor and method for inducing synthetic lethality in a cancer cell.
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