Invention Grant
- Patent Title: Method for assessing repetitive head injuries with two-dimensional magnetic resonance spectroscopy
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Application No.: US13988813Application Date: 2011-11-28
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Publication No.: US09612306B2Publication Date: 2017-04-04
- Inventor: Alexander Lin , Carolyn Mountford , Saadallah Ramadan , Robert Stern
- Applicant: Alexander Lin , Carolyn Mountford , Saadallah Ramadan , Robert Stern
- Applicant Address: US MA Boston
- Assignee: Brigham and Women's Hospital, Inc.
- Current Assignee: Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Boston
- Agency: Quarles & Brady LLP
- International Application: PCT/US2011/062211 WO 20111128
- International Announcement: WO2012/071584 WO 20120531
- Main IPC: G01R33/483
- IPC: G01R33/483 ; A61B5/055 ; A61B5/00 ; G01R33/485

Abstract:
A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.
Public/Granted literature
- US20140002075A1 METHOD FOR ASSESSING REPETITIVE HEAD INJURIES WITH TWO-DIMENSIONAL MAGNETIC RESONANCE SPECTROSCOPY Public/Granted day:2014-01-02
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