Described herein are methods and systems, including computer program products, for optimizing and controlling a building's energy consumption and comfort. A computing device receives measurements from a plurality of sensors, at least some of which are located inside the building, where the measurements include temperature readings and comfort characteristics. The computing device generates a set of thermal response coefficients based on energy characteristics of the building, the measurements from the sensors, and weather data associated with the building's location. The computing device predicts an energy response of the building based on the set of thermal response coefficients and forecasted weather. The computing device selects minimal energy requirements of the building based on an energy consumption cost associated with the building and determines energy control points based on the energy response and the minimal energy requirements. The computing device transmits the energy control points to comfort devices in the building.