Systems and methods are disclosed for providing memory channel interleaving with selective power or performance optimization. One such method involves configuring a memory address map for two or more memory devices accessed via two or more respective memory channels with an interleaved region and a linear region. The interleaved region comprises an interleaved address space for relatively higher performance use cases. The linear region comprises a linear address space for relatively lower power use cases. Memory requests are received from one or more clients. The memory requests comprise a preference for power savings or performance. Received memory requests are assigned to the linear region or the interleaved region according to the preference for power savings or performance.