An AMOLED driving device includes a control module, a voltage module, and a display panel. The control module includes a timing control unit, a data output unit, a black screen output unit, and a data output selection unit. The voltage module includes a Gamma constant voltage unit and an OLED driving voltage unit. The timing control unit generates a frame control signal (Frame_ctr) that controls the data output selection unit (14) and the OLED driving voltage unit so that a normal image is output in one frame, while a black screen is output in another frame. During the period of outputting of the black screen, a preset positive potential is switched to connect to a power supply negative potential so as to prevent the occurrence of a display defect of residual image and effectively suppress threshold voltage shifting of a second transistor.