The disclosure discloses a method and device for processing a multimedia frame and a storage medium. The method includes: judging whether there is a multimedia frame in a buffer queue with a sudden change to a time difference thereof; and playing asynchronously M multimedia frames to be processed in a current processing cycle if there is a multimedia frame in the buffer queue with a sudden change to the time difference thereof, and playing synchronously the M multimedia frames to be processed in the current processing cycle if there is no multimedia frame in the buffer queue with a sudden change to the time difference thereof and the time differences of the M multimedia frames to be processed are below a preset threshold.