A portable electronic device is provided having an audio subsystem with a plurality of audio devices, each of which is coupled to a logic subsystem via its own audio path. The portable electronic device may also include a display configured to present visual content, with the display being fixed in position relative to the plurality of audio devices. The portable electronic device further includes an orientation sensor electronically coupled to the logic subsystem, the logic subsystem being configured, using data received from the orientation sensor, (i) to determine whether the portable electronic device has been reoriented; and (ii) in response to such determination, vary operation of one or more of the audio paths.