In embodiments of RFID-based location determination for antenna power adjustment, a mobile device includes a RFID reader to interrogate and communicate with RFID tags. A control module can utilize a learning algorithm to determine a current location of the mobile device based on physical locations associated with the RFID tags, and an antenna power of a wireless transceiver can be adjusted for a signal strength of a wireless network based on the current location of the mobile device. The learning algorithm can maintain a database that includes information about particular locations or rooms within a residence, the signal strength of wireless networks at the locations, and identifiers of the RFID tags. The learning algorithm can learn context of a user's location with the mobile device to improve utilization of the antenna power of the wireless transceiver, and conserve battery power of the mobile device.