Invention Grant
- Patent Title: Inhibition of leukotriene synthesis and activity in the treatment of sonic hedgehog-associated medulloblastoma
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Application No.: US13833286Application Date: 2013-03-15
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Publication No.: US09616056B2Publication Date: 2017-04-11
- Inventor: Zeng-Jie Yang
- Applicant: Institute for Cancer Research
- Applicant Address: US PA Philadelphia
- Assignee: Institute for Cancer Research
- Current Assignee: Institute for Cancer Research
- Current Assignee Address: US PA Philadelphia
- Agency: Stadley Ronon Stevens & Young, LLP
- Main IPC: A61K31/47
- IPC: A61K31/47 ; A61K31/381 ; A61K31/404 ; A61K31/405 ; A61K31/00
Abstract:
Treating Sonic Hedgehog-Associated Medulloblastoma comprises inhibiting the synthesis or biologic activity of leukotrienes that drive Nestin expression in cancerous or precancerous granule neuron precursors and that further drive growth and proliferation of medulloblastoma cells through Nestin-mediated aberrant Sonic Hedgehog signaling.
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