The present invention relates to the field of dietary supplements, and in particular to antiviral compositions and methods of use. Compositions are described involving various combinations of Andrographis, Astragalus, Eleuthero, Isatis, Lomatium, Pelargonium, Sambucus, Scute, and/or Zinc, optionally with additional components. These combinations of supplements synergistically reduce both severity and duration of viral infections, including in particular colds and influenza, as well as providing additional benefits.