Invention Grant
- Patent Title: Pharmaceutical composition containing an endocytic motif and protein transduction domains for preventing or treating cancer
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Application No.: US14002600Application Date: 2012-03-02
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Publication No.: US09617304B2Publication Date: 2017-04-11
- Inventor: Young Woo Park , Ki Won Jo , Kyu Won Cho , Ji Hyun Park , Soon Sil Hyun , Yun Jung Park
- Applicant: Young Woo Park , Ki Won Jo , Kyu Won Cho , Ji Hyun Park , Soon Sil Hyun , Yun Jung Park
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute Of Bioscience And Biotechnology
- Current Assignee: Korea Research Institute Of Bioscience And Biotechnology
- Current Assignee Address: KR Daejeon
- Priority: KR10-2011-0018628 20110302
- International Application: PCT/KR2012/001593 WO 20120302
- International Announcement: WO2012/118353 WO 20120907
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K14/00 ; C07K14/475 ; A61K38/00
Abstract:
The present invention relates to a novel endocytic motif, and in particular, to a fusion polypeptide including the motif represented by an amino acid sequence of SEQ ID NO. 1 and a protein transduction domain, a pharmaceutical composition for preventing or treating cancer including the same, and a method for treating cancer including the step of administering the composition. The present invention shows the effects of suppressing metastasis, infiltration, angiogenesis, and growth of cancer by specifically inhibiting c-Met endocytosis and effectively inhibiting HGF/c-Met signaling pathway associated with metastasis and growth of various types of cancer cells. Therefore, the present invention can be applied to an anticancer agent for various types of cancer.
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