Invention Grant
- Patent Title: Nucleic acids encoding vitamin K expoxide reductase subunit 1 and vitamin K dependent protein expression and methods of using same
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Application No.: US11342299Application Date: 2006-01-27
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Publication No.: US09617523B2Publication Date: 2017-04-11
- Inventor: Friedrich Scheiflinger , Ernst Boehm
- Applicant: Friedrich Scheiflinger , Ernst Boehm
- Applicant Address: CH Glattpark (Opfikon) US IL Bannockburn
- Assignee: Baxalta GmbH,Baxalta Incorporated
- Current Assignee: Baxalta GmbH,Baxalta Incorporated
- Current Assignee Address: CH Glattpark (Opfikon) US IL Bannockburn
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C12N9/04
Abstract:
The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. Further, the present invention relates to a cell culture system comprising cells which contain said recombinant nucleic acids and to methods for improving the productivity of recombinant VKD protein expression in a host organism being cultured in suitable systems.
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