Refrigerators that can be used in the storage and transport of vaccines are disclosed. A refrigerator has a payload container (20) within which items can be placed for temperature-controlled storage. The payload container (20) is submerged in a reservoir (21) that contains water. The reservoir has a cooling region containing the payload container and a headspace containing water that is, in use, higher than the payload container. Cooling means, that might include a refrigeration unit (30) having cooling elements (32) or a cold thermal mass can cool water within the headspace. Where there is a refrigeration unit, a power supply, typically solar powered, can act as a source of power for the refrigeration unit. Embodiments may include a freezer compartment close to the cooling elements (32). Alternatively, the cooling region includes a pipe manifold within the payload container.