A circuit arrangement and program product selectively predicate instructions in an instruction stream by determining a first register address from an instruction, determining a second register address based on a value stored at the first register address, and determining whether to predicate the instruction based at least in part on a value stored at the second register address. Predication logic may analyze the instruction to determine the first register address, analyze a register corresponding to the first register address to determine the second register address, and communicate a predication signal to an execution unit based at least in part on the value stored at the second register address.