Multi-energy imaging is afforded with a single detector array by generating a first data set, indicative of a first radiation energy spectrum, using a first set of cells of the array, and by generating a second data set, indicative of a second radiation energy spectrum, using a second set of cells of the array (e.g., where substantially more cells are in the first set than the second). The first data set is comprised of measured data from the first set of cells and estimated data that would have been yielded from the second set of cells had the second set been configured to detect the first energy spectrum. The second data set is comprised of measured data yielded from the second set of cells and estimated data that would have been yielded from the first set of cells had the first set been configured to detect the second energy spectrum.