A method and system are provided for compensating for brightness changes in a display having an array of display pixels. The method includes storing a plurality of look-up tables, where each table has a plurality of brightness signals that provide compensation for a brightness change when the refresh rate is changed during a panel self-refresh. The method also includes using display control circuitry to determine the refresh rate associated with an input signal and to determine a compensation based on the refresh rate. The display control circuitry may, for example, use non-linear interpolation to generate a look-up table for the refresh rate. The display control circuitry may adjust the input signal based on the look-up table to produce an output signal that compensates for a brightness change at the refresh rate. The output signal may be transmitted to the array of display pixels.