A method is provided for pre-distorting an optical signal, intended to be transmitted over an optical transmission line and including a plurality of frequency division multiplexed optical sub-carriers. The optical signal is obtained from an optical conversion of an electrical signal including a plurality of frequency division multiplexed sub-carriers. This method includes obtaining a plurality of corrective factors, corresponding to the electrical sub-carriers, as a function of a plurality of values, determined for the optical sub-carriers, of a first parameter dependent on the power of the sub-carriers, and application of the corrective factors to the amplitudes of the corresponding electrical sub-carriers, so as to equalize, at the output of the optical transmission line, the values of the first parameter for the sub-carriers of the optical signal.