An information handling system (IHS) automatically responds to a change in cooling medium that cools functional components. A cooling medium sensor senses a material characteristic of the cooling medium. A thermal management controller determines whether the material characteristic received from the cooling medium sensor is in one of a first range that is associated with the air cooling medium and a second range that is associated with the liquid cooling medium. In response to determining that the material characteristic is within the second range, the thermal management controller disables a thermal mitigation component that reduces a temperature of the functional components of the IHS.