Invention Grant
- Patent Title: Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
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Application No.: US14811017Application Date: 2015-07-28
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Publication No.: US09623100B2Publication Date: 2017-04-18
- Inventor: Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
- Applicant: Wyeth LLC
- Applicant Address: US NY New York
- Assignee: Wyeth LLC
- Current Assignee: Wyeth LLC
- Current Assignee Address: US NY New York
- Agent Keith D. Hutchinson; Matthew J. Pugmire
- Main IPC: A61K39/085
- IPC: A61K39/085 ; A61K47/48 ; C08B37/00 ; A61K39/00
Abstract:
The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carbonyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).
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