The method of manufacturing a three-dimensional structure, in which the three-dimensional structure is manufactured by laminating a layer, includes the steps of: forming the layer using a three-dimension formation composition containing a particle and a light stabilizer A; and discharging a binding solution containing a binder and a light stabilizer B to the layer, in which, when the content ratio of the light stabilizer A contained in the three-dimension formation composition is represented by A (mass %) and the content ratio of the light stabilizer B contained in the binding solution is represented by B, a relationship of 2≦A/B≦4 is satisfied.