Invention Grant
- Patent Title: Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
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Application No.: US14290877Application Date: 2014-05-29
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Publication No.: US09624256B2Publication Date: 2017-04-18
- Inventor: Thomas Piccariello , John D. Price , Robert A. Oberlender , Michaela E. Mulhare , Mary C. Spencer , Scott B. Palmer
- Applicant: SYNTHONICS, INC.
- Applicant Address: US VA Blacksburg
- Assignee: SYNTHONICS, INC.
- Current Assignee: SYNTHONICS, INC.
- Current Assignee Address: US VA Blacksburg
- Agency: Brinks Gilson & Lione
- Agent Ryan L. Marshall
- Main IPC: C07F15/00
- IPC: C07F15/00 ; A61K31/28 ; C07H17/02 ; A61K31/165 ; A61K31/166 ; A61K31/295 ; A61K31/351 ; A61K31/4422 ; A61K31/7048 ; A61K45/06 ; A61K47/48 ; C07F3/00 ; C07F3/02 ; C07F3/06 ; C07F15/02 ; C07F15/04
Abstract:
A coordination complex having a physiologically acceptable pKa includes a metal and a biologically active agent. The pKa of the coordination complex is less than the pKa of the biologically active agent. A pharmaceutical solution for treating a patient includes a coordination complex and water, wherein the coordination complex is at least partially soluble in the water at physiological pH and in a therapeutically efficacious concentration. A method for treating a patient includes administering a pharmaceutical solution including a coordination complex and water to a patient in need of a biologically active agent.
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