Invention Grant
- Patent Title: Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species
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Application No.: US14090679Application Date: 2013-11-26
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Publication No.: US09624270B2Publication Date: 2017-04-18
- Inventor: James Leif Smith , Akshaya Ravichandran , Shien Lu , Ganyu Gu
- Applicant: THE TEXAS A&M UNIVERSITY SYSTEM , MISSISSIPPI STATE UNIVERSITY
- Applicant Address: US MS Starkville US TX College Station
- Assignee: MISSISSIPPI STATE UNIVERSITY,THE TEXAS A&M UNIVERSITY SYSTEM
- Current Assignee: MISSISSIPPI STATE UNIVERSITY,THE TEXAS A&M UNIVERSITY SYSTEM
- Current Assignee Address: US MS Starkville US TX College Station
- Agency: Butler Snow LLP
- Main IPC: C07K7/54
- IPC: C07K7/54 ; A61K38/12 ; A01N43/713 ; A01N63/00 ; A01N63/02 ; C12N9/16 ; C07K7/56
Abstract:
Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
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