Invention Grant
- Patent Title: Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
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Application No.: US14003963Application Date: 2012-03-09
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Publication No.: US09624307B2Publication Date: 2017-04-18
- Inventor: Matthias Nahrendorf , Ralph Weissleder , Gerhard Dickneite , Guido Stoll , Marc Nolte
- Applicant: Matthias Nahrendorf , Ralph Weissleder , Gerhard Dickneite , Guido Stoll , Marc Nolte
- Applicant Address: US MA Boston DE Marburg
- Assignee: The General Hospital Corporation,CSL Behring GmbH
- Current Assignee: The General Hospital Corporation,CSL Behring GmbH
- Current Assignee Address: US MA Boston DE Marburg
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: EP11157555 20110309
- International Application: PCT/EP2012/054142 WO 20120309
- International Announcement: WO2012/120124 WO 20120913
- Main IPC: A61K38/48
- IPC: A61K38/48 ; C07K14/81 ; C07K16/40 ; A61K38/55 ; A61K38/57 ; A61K49/00 ; A61K49/14 ; G01N33/50 ; A61K39/395 ; C07K16/36
Abstract:
Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.
Public/Granted literature
- US20140072572A1 FACTOR XII INHIBITORS FOR THE TREATMENT OF SILENT BRAIN ISCHEMIA AND ISCHEMIA OF OTHER ORGANS Public/Granted day:2014-03-13
Information query
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