Invention Grant
- Patent Title: Genetically stable live attenuated respiratory syncytial virus vaccine and its production
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Application No.: US14394226Application Date: 2013-03-13
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Publication No.: US09624475B2Publication Date: 2017-04-18
- Inventor: Peter L. Collins , Cindy L. Luongo , Ursula J. Buchholz , Brian R. Murphy
- Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2013/030836 WO 20130313
- International Announcement: WO2013/154728 WO 20131017
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/12 ; C07K14/005 ; A61K39/00

Abstract:
Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
Public/Granted literature
- US20150118732A1 GENETICALLY STABLE LIVE ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINE AND ITS PRODUCTION Public/Granted day:2015-04-30
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