Invention Grant
- Patent Title: DNA sequencing by synthesis using Raman and infrared spectroscopy detection
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Application No.: US14119846Application Date: 2012-05-23
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Publication No.: US09624539B2Publication Date: 2017-04-18
- Inventor: Jingyue Ju , Jian Wu , Zengmin Li
- Applicant: Jingyue Ju , Jian Wu , Zengmin Li
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White
- International Application: PCT/US2012/039198 WO 20120523
- International Announcement: WO2012/162429 WO 20121129
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H19/06 ; C07H19/16 ; C07H21/00
Abstract:
This invention provides nucleoside triphosphate analogs having the structure: wherein B is a base and is adenine, guanine, cytosine, uracil or thymine, wherein R″ is an OH or an H, and wherein R′ is azidomethyl, a hydrocarbyl, or a substituted hydrocarbyl, and which has a Raman spectroscopy peak with wavenumber from 2000 cm−1 to 2300 cm−1 or a Fourier transform-infrared spectroscopy spectroscopy peak with wavenumber from 2000 cm−1 to 2300 cm−1, and also to methods of DNA sequencing and SNP detection.
Public/Granted literature
- US20150080232A1 DNA SEQUENCING BY SYNTHESIS USING RAMAN AND INFRARED SPECTROSCOPY DETECTION Public/Granted day:2015-03-19
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