Invention Grant
- Patent Title: Combination of biomarkers for the detection and evaluation of hepatitis fibrosis
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Application No.: US13984702Application Date: 2012-02-09
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Publication No.: US09624541B2Publication Date: 2017-04-18
- Inventor: Bénédicte Watelet , Tarik Asselah , Ivan Bieche , Isabelle Catherine Batxelli , Nathalie Jullian , Michel Vidaud , Patrick Marcellin , Daniel Laune , Mohammad Afshar , Eve Laure Mathieu
- Applicant: Bénédicte Watelet , Tarik Asselah , Ivan Bieche , Isabelle Catherine Batxelli , Nathalie Jullian , Michel Vidaud , Patrick Marcellin , Daniel Laune , Mohammad Afshar , Eve Laure Mathieu
- Applicant Address: FR Marnes la Coquette FR Paris FR Paris FR Paris FR Paris
- Assignee: BIO-RAD INNOVATIONS,ARIANA PHARMACEUTICALS,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee: BIO-RAD INNOVATIONS,ARIANA PHARMACEUTICALS,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee Address: FR Marnes la Coquette FR Paris FR Paris FR Paris FR Paris
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: FR1151022 20110209
- International Application: PCT/EP2012/052234 WO 20120209
- International Announcement: WO2012/107530 WO 20120816
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/576 ; C12Q1/70
Abstract:
The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being: SPP1, and at least one gene from among A2M and VIM, and at least one gene from among IL8, CXCL10 and ENG, and optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.
Public/Granted literature
- US20130323720A1 COMBINATION OF BIOMARKERS FOR THE DETECTION AND EVALUATION OF HEPATITIS FIBROSIS Public/Granted day:2013-12-05
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