A method for the dynamic printing process calibration of a printing press includes determining a calibration dataset for the colored halftones of the process colors, determining a calibration dataset for the gray halftones of the process colors, determining a weighting factor for the two calibration datasets as a function of the original print and calculating a combined calibration dataset from the two determined calibration datasets, with reference to the weighting factor. The calculated combined calibration dataset is applied to the calibration of the printing process of a printing press.