Embodiments relate generally to new and useful systems and methods for processing digital images of items to facilitate item transport and/or handling. In some embodiments, a method is provided for operating an image processing and item transport system having a computing system that includes a digital image processing component. In some embodiments, the method can involve the digital image processing component acquiring a digital image and processing the digital image to obtain a digital representation of an item represented in the digital image, to estimate a dimensional size and/or weight of the item represented in the digital image, and to convert the digital image to a format suitable for outputting. In some embodiments, the method can include processing the estimated dimensional size and/or weight to identify personnel and/or equipment capable of transporting the item represented in the digital image, and outputting a transport instruction identifying the personnel and/or equipment capable of transporting the item represented in the digital image.