A method of communicating in a picocell within a macrocell includes automatically setting an uplink transmit power of a mobile station to avoid uplink interference between the picocell and the macrocell. A disclosed example includes determining an allowable interference from the picocell to the macrocell. A path-loss between a mobile station and a macrocell is determined. An uplink transmit power of the mobile station for communicating in the picocell is determined based upon the determined allowable interference and the determined path-loss.