Methods and apparatuses are provided for controlling an uplink transmission power in wireless communication system. Information is received indicating a reference downlink carrier among a plurality of downlink carriers for measuring a pathloss. The pathloss of the indicated reference downlink carrier is measured. A transmit power control (TPC) command is received. The uplink transmission power is determined based on the TPC command and the measured pathloss. Data is transmitted using the determined uplink transmission power.