A toilet seat cover with a full-directional night lamp includes an upper lid, a seat and two supports. A cylindrical night lamp is locked on the upper lid or locked between two seat shaft sleeves at two sides of the seat. The night lamp comprises at least one electric body and at least one light-pervious tube. The electric body has at least one end thereof defined as a light source end. The light source end of the electric body is axially sleeved on and fixed to the light-pervious tube. The whole night lamp can be detachably mounted on the upper lid or locked between the two seat shaft sleeves at two sides of the seat, thereby attaining a full 360 degree emission of light and allowing the lighting emission to be free of the operation state of the toilet seat cover.