There is provided a variable size, uniform compression staple assembly for use in stapling differing thicknesses of tissues. The staple assembly includes a staple and a staple block for receipt of tissue penetrating tips of the staple. Upon assembly through tissue, the tissue penetrating tips of the staple lodge within the staple block to a depth inversely proportional to the thickness of the tissues being stapled. There is also disclosed an anvil configured for use with the staple assembly.