Invention Grant
- Patent Title: Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
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Application No.: US14597911Application Date: 2015-01-15
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Publication No.: US09636298B2Publication Date: 2017-05-02
- Inventor: Alain Ajamian , Yves Andre Chantigny , Arkadii Vaisburg , Franck Raeppel , Stephane Raeppel , Robert Deziel
- Applicant: MethylGene Inc.
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: C07D207/16
- IPC: C07D207/16 ; C07D211/60 ; C07C259/06 ; C07C271/60 ; C07C275/16 ; C07C309/15 ; C07D239/557 ; C07D241/08 ; C07D263/22 ; C07D205/04 ; C07D273/08 ; C07D211/34 ; C07D211/44 ; C07D211/58 ; C07D211/62 ; A61K31/223 ; A61K31/40 ; A61K31/661 ; A61K31/495 ; A61K31/5377 ; A61K31/397 ; A61K45/06 ; A61K9/00 ; A61K31/5375 ; C07D309/12 ; C07D295/185 ; C07D295/192 ; C07D295/205 ; C07F9/09
Abstract:
The invention relates to prodrugs for use in the inhibition of histone deacetylase. The prodrugs of the present invention have good aqueous solubility and good aqueous stability. The prodrugs of the invention advantageously are metabolized to the active ingredient in plasma or in the blood stream of a warm-blooded animal. The invention also provides compositions and, and methods for making the prodrugs, and methods for using the prodrugs to treat fungal infections.
Public/Granted literature
- US20150203517A1 Prodrugs of Compounds that Enhance Antifungal Activity and Compositions of Said Prodrugs Public/Granted day:2015-07-23
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